The Effects of Short-Term Chronic Ethanol Intoxication and Ethanol Withdrawal on the Molecular Composition of the Rat Hippocampus by FT-IR Spectroscopy

Elibol-Can B., Jakubowska-Dogru E., Severcan M., Severcan F.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, cilt.35, sa.11, ss.2050-2062, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1111/j.1530-0277.2011.01556.x
  • Dergi Adı: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2050-2062
  • Anahtar Kelimeler: Ethanol Abuse, Ethanol Withdrawal, Rats, Hippocampus, FT-IR Spectroscopy, TRANSFORM-INFRARED-SPECTROSCOPY, PROTEIN SECONDARY STRUCTURE, PHYSICAL-DEPENDENCE, LIPID-PEROXIDATION, ALCOHOL, BRAIN, INDUCTION, LIVER, TOLERANCE, MEMORY
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background: The numerous adverse effects of ethanol abuse and ethanol withdrawal on biological systems are well documented. Conversely, the understanding of the molecular mechanisms underlying these pathological effects is still incomplete. This study was undertaken to investigate the effects of short-term chronic ethanol administration and ethanol withdrawal on the molecular structure and function of hippocampal tissue, a brain region important for mnemonic processes and known to be highly susceptible to ethanol intoxication.