The Effects of Short-Term Chronic Ethanol Intoxication and Ethanol Withdrawal on the Molecular Composition of the Rat Hippocampus by FT-IR Spectroscopy

Elibol-Can B., Jakubowska-Dogru E., Severcan M., Severcan F.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, vol.35, no.11, pp.2050-2062, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 11
  • Publication Date: 2011
  • Doi Number: 10.1111/j.1530-0277.2011.01556.x
  • Journal Name: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2050-2062
  • Keywords: Ethanol Abuse, Ethanol Withdrawal, Rats, Hippocampus, FT-IR Spectroscopy, TRANSFORM-INFRARED-SPECTROSCOPY, PROTEIN SECONDARY STRUCTURE, PHYSICAL-DEPENDENCE, LIPID-PEROXIDATION, ALCOHOL, BRAIN, INDUCTION, LIVER, TOLERANCE, MEMORY
  • Middle East Technical University Affiliated: Yes

Abstract

Background: The numerous adverse effects of ethanol abuse and ethanol withdrawal on biological systems are well documented. Conversely, the understanding of the molecular mechanisms underlying these pathological effects is still incomplete. This study was undertaken to investigate the effects of short-term chronic ethanol administration and ethanol withdrawal on the molecular structure and function of hippocampal tissue, a brain region important for mnemonic processes and known to be highly susceptible to ethanol intoxication.