Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes

Ozalp V. C. , Cam D., Hernandez F. J. , Hernandez L. I. , Schafer T., ÖKTEM H. A.

ANALYST, vol.141, no.8, pp.2595-2599, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 141 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1039/c6an00273k
  • Title of Journal : ANALYST
  • Page Numbers: pp.2595-2599


A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.