Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek N. S., Bal I. B., SARA M. Y., Onur R., Severcan F.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, cilt.1840, sa.1, ss.406-415, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1840 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.bbagen.2013.09.010
  • Dergi Adı: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.406-415
  • Anahtar Kelimeler: Statin, Extensor digitorum longus, Soleus, Diaphragm, Contractility, Fourier Transform Infrared spectroscopy, COA REDUCTASE INHIBITORS, TRANSFORM INFRARED-SPECTROSCOPY, COENZYME-A REDUCTASE, RYANODINE RECEPTORS, LIPID-PEROXIDATION, MEMBRANE FLUIDITY, GENE-EXPRESSION, STATIN, RAT, CHOLESTEROL
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.