Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles

Ozek N. S., Bal I. B., SARA M. Y., Onur R., Severcan F.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, vol.1840, no.1, pp.406-415, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 1840 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1016/j.bbagen.2013.09.010
  • Journal Name: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.406-415
  • Keywords: Statin, Extensor digitorum longus, Soleus, Diaphragm, Contractility, Fourier Transform Infrared spectroscopy, COA REDUCTASE INHIBITORS, TRANSFORM INFRARED-SPECTROSCOPY, COENZYME-A REDUCTASE, RYANODINE RECEPTORS, LIPID-PEROXIDATION, MEMBRANE FLUIDITY, GENE-EXPRESSION, STATIN, RAT, CHOLESTEROL
  • Middle East Technical University Affiliated: Yes

Abstract

Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.