Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern


Iseri O. D. , Kars M. D. , Arpaci F., Atalay C., Pak I., GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, cilt.65, ss.40-45, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 65 Konu: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.biopha.2010.10.004
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Sayfa Sayıları: ss.40-45

Özet

Purpose: Multidrug resistance is resistance to structurally unrelated anticancer agents. Large-scale expression analysis by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to MDR. This study demonstrates alterations in expression levels of several genes related to epithelial-mesenchymal transition (EMT) in paclitaxel, docetaxel, and doxorubicin resistant MCF-7 cells.