Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern

Iseri O. D., Kars M. D., Arpaci F., Atalay C., Pak I., GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, vol.65, no.1, pp.40-45, 2011 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 65 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1016/j.biopha.2010.10.004
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.40-45
  • Keywords: Multidrug resistance, EMT, Breast cancer, REPRESSES E-CADHERIN, BREAST-CANCER, TUMOR PROGRESSION, SLUG EXPRESSION, METASTASIS, INVASION, OVEREXPRESSION, PROTEINS, BEHAVIOR, SNAIL
  • Middle East Technical University Affiliated: Yes

Abstract

Purpose: Multidrug resistance is resistance to structurally unrelated anticancer agents. Large-scale expression analysis by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to MDR. This study demonstrates alterations in expression levels of several genes related to epithelial-mesenchymal transition (EMT) in paclitaxel, docetaxel, and doxorubicin resistant MCF-7 cells.