Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern

Iseri O. D., Kars M. D., Arpaci F., Atalay C., Pak I., GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, cilt.65, sa.1, ss.40-45, 2011 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.biopha.2010.10.004
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.40-45
  • Anahtar Kelimeler: Multidrug resistance, EMT, Breast cancer, REPRESSES E-CADHERIN, BREAST-CANCER, TUMOR PROGRESSION, SLUG EXPRESSION, METASTASIS, INVASION, OVEREXPRESSION, PROTEINS, BEHAVIOR, SNAIL
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Purpose: Multidrug resistance is resistance to structurally unrelated anticancer agents. Large-scale expression analysis by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to MDR. This study demonstrates alterations in expression levels of several genes related to epithelial-mesenchymal transition (EMT) in paclitaxel, docetaxel, and doxorubicin resistant MCF-7 cells.