Kinetic resolution of primary alcohols having remote stereogenic centers: lipase mediated kinetic resolution of (+/-)-3-chloro-3-arylpropanols

ISLEYEN A., Tanyeli C. , Dogan O.

TETRAHEDRON-ASYMMETRY, cilt.17, sa.10, ss.1561-1567, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 10
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.tetasy.2006.06.001
  • Sayfa Sayıları: ss.1561-1567


Kinetic resolutions of (+/-)-3-chloro-3-arylpropanols by lipase mediated acetylation are described for the first time. Acetylation with CCL provided the best enantioselectivity amongst the enzymes used. Enantiomerically enriched products were obtained with up to 78% ee after two successive lipase-catalyzed acetylations. Different substituents on the aromatic ring and bromide, instead of chloride, on the substrates were found to have no drastic influence on the enantioselectivity of the reaction. (c) 2006 Elsevier Ltd. All rights reserved.