Kinetic resolution of primary alcohols having remote stereogenic centers: lipase mediated kinetic resolution of (+/-)-3-chloro-3-arylpropanols

ISLEYEN A., Tanyeli C., Dogan O.

TETRAHEDRON-ASYMMETRY, cilt.17, sa.10, ss.1561-1567, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.tetasy.2006.06.001
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1561-1567
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Kinetic resolutions of (+/-)-3-chloro-3-arylpropanols by lipase mediated acetylation are described for the first time. Acetylation with CCL provided the best enantioselectivity amongst the enzymes used. Enantiomerically enriched products were obtained with up to 78% ee after two successive lipase-catalyzed acetylations. Different substituents on the aromatic ring and bromide, instead of chloride, on the substrates were found to have no drastic influence on the enantioselectivity of the reaction. (c) 2006 Elsevier Ltd. All rights reserved.