Selenium alters the lipid content and protein profile of rat heart: An FTIR micro spectroscopic study

Toyran N., Turan B., Severcan F.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, cilt.458, sa.2, ss.184-193, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 458 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.abb.2006.12.012
  • Dergi Adı: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.184-193
  • Anahtar Kelimeler: heart, myocardium, vein, selenium, lipid content, protein structure, FTIR microspectroscopy, TRANSFORM INFRARED-SPECTROSCOPY, RAINBOW-TROUT LIVER, SODIUM SELENITE, IR SPECTROSCOPY, FATTY-ACIDS, MAP KINASE, PEROXIDATION, TISSUE, CELLS, DEFICIENCY
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Cardiovascular disease is one of the most important causes of morbidity and mortality in Western countries. In addition, it is well documented that selenium (Se) deficiency has been linked to cardiovascular diseases. This study was undertaken to present the effect of sodium selenite on left and right myocardia, and small veins of normal control rat heart at molecular level by using Fourier transform infrared (FTIR) microspectroscopy. The results mainly reveal that, Se treatment causes an increase in lipid content both in the saturated and unsaturated lipids, and an alteration in protein profile with a decrease in a-helix and an increase in beta-sheet structure of the rat heart which might be reflecting a slight subtoxic effect of selenium supplementation on normal rat heart at the dose used in this study. (c) 2006 Elsevier Inc. All rights reserved.