HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1


Erdem M. , Özgül İ. , Erson Bensan A. E.

Atlas Genet Cytogenet Oncol Haematol., cilt.0, no.0, ss.1, 2018 (Diğer Kurumların Hakemli Dergileri)

  • Cilt numarası: 0 Konu: 0
  • Basım Tarihi: 2018
  • Dergi Adı: Atlas Genet Cytogenet Oncol Haematol.
  • Sayfa Sayıları: ss.1

Özet

Heterogeneous nuclear ribonucleoprotein (HNRNPA1) gene maps to chromosome 12, plus strand and has 13 exons and 12 introns. There are three reported transcripts due to the alternative splicing.
HNRNPA1 is one of the most abundant and ubiquitously expressed nuclear proteins. HNRNPA1 is a member of RNA-binding protein family comprising of 20 members in humans (Dreyfuss, 1993; Pinol-Roma, Choi, Matunis, & Dreyfuss, 1988). HNRNPA1 has diverse roles in RNA splicing, telomere length maintenance, miRNA maturation and mRNA transport from nucleus to cytoplasm.