HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1

Erdem M., Özgül İ., Erson Bensan A. E.

Atlas Genet Cytogenet Oncol Haematol., vol.0, no.0, pp.1, 2018 (Peer-Reviewed Journal)

  • Publication Type: Article / Review
  • Volume: 0 Issue: 0
  • Publication Date: 2018
  • Journal Name: Atlas Genet Cytogenet Oncol Haematol.
  • Journal Indexes: Other Indexes
  • Page Numbers: pp.1
  • Middle East Technical University Affiliated: Yes

Abstract

Heterogeneous nuclear ribonucleoprotein (HNRNPA1) gene maps to chromosome 12, plus strand and has 13 exons and 12 introns. There are three reported transcripts due to the alternative splicing.
HNRNPA1 is one of the most abundant and ubiquitously expressed nuclear proteins. HNRNPA1 is a member of RNA-binding protein family comprising of 20 members in humans (Dreyfuss, 1993; Pinol-Roma, Choi, Matunis, & Dreyfuss, 1988). HNRNPA1 has diverse roles in RNA splicing, telomere length maintenance, miRNA maturation and mRNA transport from nucleus to cytoplasm.