Two concrete frames were tested by the PsD procedure. One frame was bare and the other was infilled with AAC blocks in the middle bay. The objective was to determine the effect of AAC infills on the seismic performance of reinforced concrete frames and developing an AAC strut model. Based on the test results, it was found that AAC infill panels did not modify the deformation response of the RC test frame significantly; however, shear in diagonal strut must be considered in boundary column design. A shear design procedure is proposed for the boundary columns in infilled frames. The drift limits of AAC infill panels measured during the tests were 0.005, 0.008, and 0.014 during diagonal cracking, corner crushing, and severe damage states, respectively.