Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management
Computer Methods and Programs in Biomedicine, cilt.208, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 208
- Basım Tarihi: 2021
- Doi Numarası: 10.1016/j.cmpb.2021.106256
- Dergi Adı: Computer Methods and Programs in Biomedicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Applied Science & Technology Source, BIOSIS, Biotechnology Research Abstracts, Compendex, Computer & Applied Sciences, EMBASE, INSPEC, MEDLINE
- Anahtar Kelimeler: Abdominal aortic aneurysms, disease management, aneurysm growth, clinical decision making, optimization and curve fitting, PRACTICE GUIDELINES, MAXIMUM DIAMETER, EXPANSION, SURGERY, RUPTURE, SOCIETY, SURVEILLANCE, ASSOCIATION, THROMBUS, VOLUME
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
© 2021 Elsevier B.V.Objective: The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant role in the clinical decision making process. This study aims to build a total of 21 morphological parameters from longitudinal CT scans and analyze their correlations. Furthermore, this work explores the existence of a “master curve” of AAA growth, and tests which parameters serve to enhance its predictability for clinical use. Methods: 106 CT scan images from 25 Korean AAA patients were retrospectively obtained. We subsequently computed morphological parameters, growth rates, and pair-wise correlations, and attempted to enhance the predictability of the growth for high-risk aneurysms using non-linear curve fitting and least-square minimization. Results: An exponential AAA growth model was fitted to the maximum spherical diameter, as the best representative of the growth among all parameters (r-square: 0.94) and correctly predicted to 15 of 16 validation scans based on a 95% confidence interval. AAA volume expansion rates were highly correlated (r=0.75) with thrombus accumulation rates. Conclusions: The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period.