Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management

Akkoyun E., Gharahi H., Kwon S. T. , Zambrano B. A. , Rao A., ACAR A. C. , ...More

Computer Methods and Programs in Biomedicine, vol.208, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 208
  • Publication Date: 2021
  • Doi Number: 10.1016/j.cmpb.2021.106256
  • Title of Journal : Computer Methods and Programs in Biomedicine
  • Keywords: Abdominal aortic aneurysms, disease management, aneurysm growth, clinical decision making, optimization and curve fitting, PRACTICE GUIDELINES, MAXIMUM DIAMETER, EXPANSION, SURGERY, RUPTURE, SOCIETY, SURVEILLANCE, ASSOCIATION, THROMBUS, VOLUME


© 2021 Elsevier B.V.Objective: The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant role in the clinical decision making process. This study aims to build a total of 21 morphological parameters from longitudinal CT scans and analyze their correlations. Furthermore, this work explores the existence of a “master curve” of AAA growth, and tests which parameters serve to enhance its predictability for clinical use. Methods: 106 CT scan images from 25 Korean AAA patients were retrospectively obtained. We subsequently computed morphological parameters, growth rates, and pair-wise correlations, and attempted to enhance the predictability of the growth for high-risk aneurysms using non-linear curve fitting and least-square minimization. Results: An exponential AAA growth model was fitted to the maximum spherical diameter, as the best representative of the growth among all parameters (r-square: 0.94) and correctly predicted to 15 of 16 validation scans based on a 95% confidence interval. AAA volume expansion rates were highly correlated (r=0.75) with thrombus accumulation rates. Conclusions: The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period.