Triglyceride dependent differentiation of obesity in adipose tissues by FTIR spectroscopy coupled with chemometrics

Baloglu F. K., BALOĞLU O., Heise S., Brockmann G., Severcan F.

JOURNAL OF BIOPHOTONICS, vol.10, no.10, pp.1345-1355, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 10
  • Publication Date: 2017
  • Doi Number: 10.1002/jbio.201600223
  • Journal Name: JOURNAL OF BIOPHOTONICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1345-1355
  • Keywords: Obesity, Adipose Tissue, Diagnosis, FTIR Spectroscopy, Principal Component Analysis, Hierarchical Cluster Analysis, TRANSFORM-INFRARED-SPECTROSCOPY, TOTAL-BODY FAT, INSULIN-RESISTANCE, RISK-FACTORS, MICROSPECTROSCOPY, METABOLISM, DIAGNOSIS, DISCRIMINATION, CLASSIFICATION, IDENTIFICATION
  • Middle East Technical University Affiliated: Yes

Abstract

The excess deposition of triglycerides in adipose tissue is the main reason of obesity and causes excess release of fatty acids to the circulatory system resulting in obesity and insulin resistance. Body mass index and waist circumference are not precise measure of obesity and obesity related metabolic diseases. Therefore, in the current study, it was aimed to propose triglyceride bands located at 1770-1720 cm(-1) spectral region as a more sensitive obesity related biomarker using the diagnostic potential of Fourier Transform Infrared (FTIR) spectroscopy in subcutaneous (SCAT) and visceral (VAT) adipose tissues.