Copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligand


DOĞAN Ö. , Bulut A., Polat S., Tecimer M. A.

TETRAHEDRON-ASYMMETRY, cilt.22, ss.1601-1604, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.tetasy.2011.09.003
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayıları: ss.1601-1604

Özet

A series of chiral phosphine PFAM and phosphine oxide POFAM ligands were studied for the copper-catalyzed asymmetric diethylzinc addition to enones. One of these ligands, PFAM2, was an efficient catalyst with a variety of enones to give conjugate addition products in up to 96% yield and 92% ee. (C) 2011 Elsevier Ltd. All rights reserved.