Copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligand

DOĞAN, ÖZDEMİR; Bulut, Adnan; Polat, Savas; Tecimer, M.

doi:10.1016/j.tetasy.2011.09.003

Copper-catalyzed asymmetric conjugate addition of diethylzinc to substituted chalcones using a chiral phosphine ligand

Atıf İçin Kopyala

DOĞAN Ö., Bulut A., Polat S., Tecimer M. A.

TETRAHEDRON-ASYMMETRY, cilt.22, ss.1601-1604, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22
Basım Tarihi: 2011
Doi Numarası: 10.1016/j.tetasy.2011.09.003
Dergi Adı: TETRAHEDRON-ASYMMETRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1601-1604
Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

A series of chiral phosphine PFAM and phosphine oxide POFAM ligands were studied for the copper-catalyzed asymmetric diethylzinc addition to enones. One of these ligands, PFAM2, was an efficient catalyst with a variety of enones to give conjugate addition products in up to 96% yield and 92% ee. (C) 2011 Elsevier Ltd. All rights reserved.