In this study, the change in the load-bearing system cost of a reinforced concrete office building has been investigated in relation to the earthquake regions and soil types. Three different office projects each with five stories were investigated. The structural design calculations have been made according to four different soil types and four different earthquake regions. According to each combination, concrete, steel and formwork adopted approximations were calculated to reach the rough cost of each office building. The changes in the cost of projects according to the soil type and earthquake region were examined with multiple regression analysis and analysis of variance. In general, the change in cost has been observed around 22% between first and fourth soil type and 14% between first and fourth earthquake region. (C) 2006 Elsevier Ltd. All rights reserved.