Poly(epsilon-caprolactone) composites containing gentamicin-loaded beta-tricalcium phosphate/gelatin microspheres as bone tissue supports

Sezer U. A., Aksoy E. A., Hasirci V., Hasirci N.

JOURNAL OF APPLIED POLYMER SCIENCE, cilt.127, sa.3, ss.2132-2139, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/app.37770
  • Dergi Adı: JOURNAL OF APPLIED POLYMER SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2132-2139
  • Anahtar Kelimeler: poly(epsilon-caprolactone), beta-tricalcium phosphate, gelatin, fillers, biodegradable, controlled release, antibacterial activity, ENZYMATIC DEGRADATION, MECHANICAL-PROPERTIES, REGENERATION MEMBRANE, CERAMIC MICROSPHERES, EPSILON-CAPROLACTONE, DRUG-DELIVERY, RELEASE, OSTEOCONDUCTIVITY, SCAFFOLDS, BLENDS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

In this work, novel antibacterial composites were prepared by using poly(epsilon-caprolactone) (PCL) as the main matrix material, and gentamicin-loaded microspheres composed of beta-tricalcium phosphate (beta-TCP) and gelatin. The purpose is to use this biodegradable material as a support for bone tissue. This composite system is expected to enhance bone regeneration by the presence of beta-TCP and prevent a possible infection that might occur around the defected bone region by the release of gentamicin. The effects of the ratio of the beta-TCP/gelatin microspheres on the morphological, mechanical, and degradation properties of composite films as well as in vitro antibiotic release and antibacterial activities against Escherichia coli and Staphylococcus aureus were investigated. The results showed that the composites of PCL and beta-TCP/gelatin microspheres had antibacterial activities for both bacteria. (C) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013