Development of a Reconstructed Cornea from Collagen-Chondroitin Sulfate Foams and Human Cell Cultures

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Vrana N. E., Builles N., Justin V., Bednarz J., Pellegrini G., Ferrari B., ...More

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol.49, no.12, pp.5325-5331, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 12
  • Publication Date: 2008
  • Doi Number: 10.1167/iovs.07-1599
  • Journal Name: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5325-5331
  • Middle East Technical University Affiliated: Yes

Abstract

PURPOSE. To develop an artificial cornea, the ability to coculture the different cell types present in the cornea is essential. Here the goal was to develop a full-thickness artificial cornea using an optimized collagen-chondroitin sulfate foam, with a thickness close to that of human cornea, by coculturing human corneal epithelial and stromal cells and transfected human endothelial cells.