Development of a Reconstructed Cornea from Collagen-Chondroitin Sulfate Foams and Human Cell Cultures

Vrana, N.; Builles, Nicolas; Justin, Virginie; Bednarz, Jurgen; Pellegrini, Graziella; Ferrari, Barbara; Damour, Odile; Hulmes, David; Hasirci, VASIF

doi:10.1167/iovs.07-1599

Development of a Reconstructed Cornea from Collagen-Chondroitin Sulfate Foams and Human Cell Cultures

Vrana N. E., Builles N., Justin V., Bednarz J., Pellegrini G., Ferrari B., ...More

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol.49, no.12, pp.5325-5331, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 49 Issue: 12
Publication Date: 2008
Doi Number: 10.1167/iovs.07-1599
Journal Name: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.5325-5331
Open Archive Collection: AVESIS Open Access Collection
Middle East Technical University Affiliated: Yes

Abstract

PURPOSE. To develop an artificial cornea, the ability to coculture the different cell types present in the cornea is essential. Here the goal was to develop a full-thickness artificial cornea using an optimized collagen-chondroitin sulfate foam, with a thickness close to that of human cornea, by coculturing human corneal epithelial and stromal cells and transfected human endothelial cells.