Mass spectrometry as a tool in dendrimer chemistry: from self-assembling dendrimers to dendrimer gas-phase host-guest chemistry

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Schalley C. A., Baytekin B., Baytekin H. T., Engeser M., Felder T., Rang A.

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, vol.19, no.8-9, pp.479-490, 2006 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 19 Issue: 8-9
• Publication Date: 2006
• Doi Number: 10.1002/poc.1105
• Journal Name: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.479-490
• Keywords: supramolecular chemistry, mass spectrometry, gas-phase chemistry, dendrimers, self-assembly, molecular tweezers, defects, fragmentation mechanisms, dendritic effects, ASSISTED-LASER-DESORPTION/IONIZATION, POLY(PROPYLENE IMINE) DENDRIMERS, SUPRAMOLECULAR CHEMISTRY, MOLECULAR RECOGNITION, POLYMERS, SQUARES, FULLERODENDRIMERS, ENCAPSULATION, TETRANUCLEAR, COMPLEXES
• Middle East Technical University Affiliated: No

Abstract

Mass spectrometry has played a significant role in dendrimer chemistry, because it serves as an excellent analytical means to determine the purity and analyze the nature of defects even for higher generations. However, a mass spectrometer can also be used as a laboratory to study isolated dendrimer molecules in the gas phase or their host-guest complexes. Since the properties of molecules under environment-free conditions are often quite different from those in solution, their gas-phase chemistry provides valuable new insight into properties which cannot easily be studied in solution. This article summarizes some of our work on characterizing self-assembling metallo-supramolecular dendrimers, on analyzing ionization artifacts, on the differentiation between several, sometimes even isomeric defects through tandem MS experiments, and finally on the analysis of a surprisingly clear dendritic effect occurring in the fragmentation of dendritic host-guest complexes. Copyright (c) 2006 John Wiley & Sons, Ltd.