CCL- and PLE-catalyzed reverse enantiomeric separation of various (+/-)-2-thienylcarbinols


Tanyeli C. , Akhmedov I., Ozdemirhan D.

ENANTIOMER, cilt.6, ss.259-265, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 6 Konu: 5
  • Basım Tarihi: 2001
  • Dergi Adı: ENANTIOMER
  • Sayfa Sayıları: ss.259-265

Özet

(+/-)-2-Thienylcarbinols and their O-acetyl derivatives were resolved in reverse separation by CCL and PLE catalysed hydrolysis to afford optically active 2-thienylcarbinols in 35%-99% e.e. that are valuable chiral building blocks, in particular in the synthesis of pheromones and some alkoloid type natural products. Absolute configurations were determined by the correlation of specific rotation values with the literature and by transforming into the corresponding secondary alcohols via reductive desulfurization by Ra-Ni.