CCL- and PLE-catalyzed reverse enantiomeric separation of various (+/-)-2-thienylcarbinols


Tanyeli C. , Akhmedov I., Ozdemirhan D.

ENANTIOMER, vol.6, no.5, pp.259-265, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 5
  • Publication Date: 2001
  • Title of Journal : ENANTIOMER
  • Page Numbers: pp.259-265

Abstract

(+/-)-2-Thienylcarbinols and their O-acetyl derivatives were resolved in reverse separation by CCL and PLE catalysed hydrolysis to afford optically active 2-thienylcarbinols in 35%-99% e.e. that are valuable chiral building blocks, in particular in the synthesis of pheromones and some alkoloid type natural products. Absolute configurations were determined by the correlation of specific rotation values with the literature and by transforming into the corresponding secondary alcohols via reductive desulfurization by Ra-Ni.