Reduction of surgery-induced peritoneal adhesions by continuous release of streptokinase from a drug delivery system

Yagmurlu A., Barlas M., Gursel I., Gokcora I.

EUROPEAN SURGICAL RESEARCH, cilt.35, sa.1, ss.46-49, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1159/000067035
  • Dergi Adı: EUROPEAN SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.46-49
  • Anahtar Kelimeler: peritoneal adhesions, streptokinase, drug delivery systems, POSTOPERATIVE ABDOMINAL ADHESIONS, PREVENTION, MODEL
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Postoperative abdominal adhesions may lead to intestinal obstruction and infertility. The effect of continuous release of streptokinase to the peritoneal cavity on postoperative adhesions was examined under experimental conditions. Peritoneal adhesions were induced in rats and the animals were further treated by intraperitoneal administration of streptokinase solution, polyhydroxy-butyrate-co-hydroxyvalerate (PHBV) membrane alone and streptokinase loaded PHBV membrane and compared to sham operated and untreated groups. Formation of adhesions was evaluated by quantitative macroscopic grading, histopathologically with light microscopy, on the following week. Streptokinase loaded PHBV prevented postoperative adhesion formation in 90% of the cases. PHBV membrane alone also reduced the severity of adhesions due to its anti-adhesive properties. Histopathological examination revealed limited foreign body reaction due to PHBV. Continuous streptokinase activity in the peritoneal cavity during early post-surgical period prevents postoperative adhesion. Copyright (C) 2003 S. Karger AG, Basel.