The present study investigated possible Type C personality-quality of life (QOL) relationship, and the moderating role of perceived social support in this relation among 101 postoperative breast cancer patients. Participants were from different cities in Turkey but receiving treatment in the capital, Ankara. Obtained data were analyzed by moderated regression analysis. According to the results, Type C personality was not related to the QOL of participants, however, higher perceived social support was associated with better QOL in patients. Also, perceived social support moderated Type C personality-QOL relation. Accordingly, patients high on Type C personality and perceived social support had the highest QOL. In contrast, patients high on Type C personality and low on perceived social support had the lowest QOL. Findings, as well as the strengths and limitations of the study, were discussed in the light of the relevant literature. As a possible clinical implication, enhancement of social support networks of the patients were suggested.