The seismic behavior of a 1/2 scaled, three-story three-bay RC frame with masonry infill walls was studied experimentally and numerically. Pseudo-dynamic test results showed that despite following the column design provisions of modern seismic codes and neglecting the presence of infill walls, shear induced damage is unavoidable in the boundary columns. A finite element model was validated by using the results of available one-story one-bay frame tests in the literature. Simulations of the examined test frame demonstrated that boundary columns are subjected to shear demands in excess of their shear capacity. Seismic assessment of the test frame was conducted by using ASCE/SEI 41-06 (2006) guidelines and the obtained results were compared with the damage observed during experiment. ASCE/SEI 41-06 method for the assessment of boundary columns was found unsatisfactory in estimating the observed damage. Damage estimations were improved when the strain limits were used within the plastic hinge zone instead of column full height.