© 2021 Independent University of Moscow.The present paper is devoted to a scheme-theoretic version of holomorphic multi-operator functional calculus. We construct a functional calculus with sections of a quasi-coherent sheaf on a noe-therian scheme, and prove analogs of the known results from multivari-able holomorphic functional calculus over Fréchet modules. A spectrum of an algebraic variety over an algebraically closed field is considered. This concept reflects Taylor joint spectrum from operator theory. Ev-ery algebraic variety turns out to be a joint spectrum of the coordinate multiplication operators over its coordinate ring.