A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol-Cu(I) Structure


Oezcubukcu S. , ÖZKAL E., JİMENO C., Pericas M. A.

ORGANIC LETTERS, cilt.11, ss.4680-4683, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 20
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1021/ol9018776
  • Dergi Adı: ORGANIC LETTERS
  • Sayfa Sayıları: ss.4680-4683

Özet

A new tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol ligand 3 has been prepared by a triple Cu(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable complex with CuCl, which catalyzes the Huisgen 1,3-dipolar cycloaddition on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make 3-CuCl an outstanding catalyst for CuAAC.