Role of ABCB1 and ABCC1 Gene Induction on Survival in Locally Advanced Breast Cancer

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Atalay C., DEMİRKAZIK A., GÜNDÜZ U.

JOURNAL OF CHEMOTHERAPY, vol.20, no.6, pp.734-739, 2008 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 20 Issue: 6
• Publication Date: 2008
• Doi Number: 10.1179/joc.2008.20.6.734
• Journal Name: JOURNAL OF CHEMOTHERAPY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.734-739
• Keywords: Breast cancer, ABCB1, ABCC1, survival, MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, DRUG-RESISTANCE, EXPRESSION, CHEMOTHERAPY, PROTEIN, CARCINOMA, THERAPY
• Middle East Technical University Affiliated: Yes

Abstract

Drug resistance to chemotherapy in patients with locally advanced breast cancer results in a decrease in treatment efficacy and in patient survival. This study aimed to evaluate the impact of ABCB1 and ABCC1 gene induction during chemotherapy on disease-free and overall survival of breast cancer patients.