Role of ABCB1 and ABCC1 Gene Induction on Survival in Locally Advanced Breast Cancer


Atalay C., DEMİRKAZIK A., GÜNDÜZ U.

JOURNAL OF CHEMOTHERAPY, vol.20, no.6, pp.734-739, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1179/joc.2008.20.6.734
  • Title of Journal : JOURNAL OF CHEMOTHERAPY
  • Page Numbers: pp.734-739
  • Keywords: Breast cancer, ABCB1, ABCC1, survival, MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, DRUG-RESISTANCE, EXPRESSION, CHEMOTHERAPY, PROTEIN, CARCINOMA, THERAPY

Abstract

Drug resistance to chemotherapy in patients with locally advanced breast cancer results in a decrease in treatment efficacy and in patient survival. This study aimed to evaluate the impact of ABCB1 and ABCC1 gene induction during chemotherapy on disease-free and overall survival of breast cancer patients.