Carbocyclic 4'-epi-formycin

Zhou J., Yang M., Akdag A., Wang H., Schneller S. W.

TETRAHEDRON, vol.64, no.2, pp.433-438, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1016/j.tet.2007.10.054
  • Journal Name: TETRAHEDRON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.433-438
  • Middle East Technical University Affiliated: No

Abstract

Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4'-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells. (c) 2007 Elsevier Ltd. All rights reserved.