Carbocyclic 4'-epi-formycin


Zhou J., Yang M., Akdag A. , Wang H., Schneller S. W.

TETRAHEDRON, cilt.64, ss.433-438, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 64 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.tet.2007.10.054
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.433-438

Özet

Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4'-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells. (c) 2007 Elsevier Ltd. All rights reserved.