Fam-Ti catalyzed enantioselective alkynylation of aldehydes


KOYUNCU H., Dogan O.

ORGANIC LETTERS, vol.9, no.17, pp.3477-3479, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 17
  • Publication Date: 2007
  • Doi Number: 10.1021/ol701535y
  • Journal Name: ORGANIC LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3477-3479
  • Middle East Technical University Affiliated: Yes

Abstract

Ferrocenyl-substituted aziridinylmethanol (Fam-1) has been used as a chiral catalyst with titanium for enantioselective alkynylation of aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated aldehydes to give the corresponding propargylic alcohols in up to 96% yield and 96% ee. The ligand can be prepared easily and recycled.