Fam-Ti catalyzed enantioselective alkynylation of aldehydes
ORGANIC LETTERS, vol.9, no.17, pp.3477-3479, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 9 Issue: 17
- Publication Date: 2007
- Doi Number: 10.1021/ol701535y
- Journal Name: ORGANIC LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.3477-3479
- Middle East Technical University Affiliated: Yes
Abstract
Ferrocenyl-substituted aziridinylmethanol (Fam-1) has been used as a chiral catalyst with titanium for enantioselective alkynylation of aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated aldehydes to give the corresponding propargylic alcohols in up to 96% yield and 96% ee. The ligand can be prepared easily and recycled.