Fam-Ti catalyzed enantioselective alkynylation of aldehydes

KOYUNCU H., Dogan O.

ORGANIC LETTERS, cilt.9, sa.17, ss.3477-3479, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 17
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1021/ol701535y
  • Dergi Adı: ORGANIC LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3477-3479
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Ferrocenyl-substituted aziridinylmethanol (Fam-1) has been used as a chiral catalyst with titanium for enantioselective alkynylation of aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated aldehydes to give the corresponding propargylic alcohols in up to 96% yield and 96% ee. The ligand can be prepared easily and recycled.