The thermoelastic-plastic deformations of internal heat-generating tubes are investigated by considering the temperature dependence of the thermal conductivity coefficient, Young's modulus, the coefficient of thermal expansion, and the yield limit of the material. A model describing the elastic-plastic behavior of the tube is developed. The model consists of a system of two second-order ordinary differential equations and a first-order ordinary differential equation involving nonlinear temperature-dependent coefficients. The computer solution of the model is obtained, and the results are compared with the analytical solution that assumes constant thermomechanical properties. It is found that the difference between the two solutions becomes significant in the regions of high temperatures.