FT-IR spectroscopy in diagnosis of diabetes in rat animal model

SEVERCAN F., Bozkurt O., Gurbanov R., Gorgulu G.

JOURNAL OF BIOPHOTONICS, vol.3, pp.621-631, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3
  • Publication Date: 2010
  • Doi Number: 10.1002/jbio.201000016
  • Journal Name: JOURNAL OF BIOPHOTONICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.621-631
  • Keywords: FT-IR spectroscopy, diagnosis, diabetes, muscle, liver, kidney, membrane, TRANSFORM INFRARED-SPECTROSCOPY, INDUCED INSULIN RESISTANCE, SKELETAL-MUSCLE FIBERS, BLOOD-RETINAL BARRIER, ULTRASTRUCTURAL ALTERATIONS, CLUSTER-ANALYSIS, HEART-DISEASE, MELLITUS, LIVER, METABOLISM
  • Middle East Technical University Affiliated: Yes

Abstract

In recent years, Fourier Transform Infrared (FT-IR) spectroscopy has had an increasingly important role in the field of pathology and diagnosis of disease states. In the current study, FT-IR spectroscopy together with cluster analysis were used as a diagnostic tool in the discrimination of diabetic samples from control ones in rat kidney plasma membrane apical sides (brush-border membranes), liver microsomal membranes and Extensor digitorum longus (EDL) and Soleus (SOL) skeletal muscle tissues