Mesoporous silica-based electrochemical biosensors in the determination of cancer biomarkers: Current progress on analytical performance and future trends

Erkmen C., Sanko V., ÖZTÜRK B. Ö., Quinchía J., Orozco J., KURALAY F.

TrAC - Trends in Analytical Chemistry, vol.179, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 179
  • Publication Date: 2024
  • Doi Number: 10.1016/j.trac.2024.117876
  • Journal Name: TrAC - Trends in Analytical Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Analytical Abstracts, Chemical Abstracts Core, Chimica, Compendex, Food Science & Technology Abstracts, DIALNET
  • Keywords: Cancer biomarker, Electrochemical sensor, Real samples, Silica-based nanomaterial
  • Middle East Technical University Affiliated: No

Abstract

Early and precise diagnosis can prevent the severe effects of cancer, which is one of the leading health problems worldwide. Electrochemical (bio)sensors are at the forefront of technologies for this purpose due to their capacity to rapidly screen biomarkers, which is crucial for cancer diagnosis and health status monitoring. With the advantages of electrochemical analysis and nanomaterials' improved structural/chemical features, electrochemical biosensors offer outstanding performance for specific biomarker detection. Among different nanomaterials, silica-based nanomaterials contribute to developing enhanced (multi)functional sensing platforms. This review discusses the applications of electrochemical biosensors based on mesoporous silica nanomaterials for determining cancer biomarkers in biological fluids. Silica nanomaterials' types, synthesis methods, and properties are discussed comparatively. The current uses and developments of electrochemical biosensors and their functions in the last fifteen years are presented for practical applications in cancer biomarkers detection and monitoring to end with some concluding remarks, perspectives, and trends.