The low solubility of traditional herbal products is a major drawback that hinders the efficacy of their use in medicinal products. In this study, a new drug delivery mechanism was developed by encapsulating Aloe Vera extract in phospholipids to develop robust and effective anti-carcinogenic gel material. The aloe vera extract-phospholipid complex has been characterized for its morphological properties using scanning electron microscopy (SEM), X-ray diffraction (XRD), and dynamic light scattering techniques. The particles of phytosome gel are approximately spherical with an average particle size 2492 nm, and a negative zeta potential of similar to 14 mV. In-vitro antioxidant tests of prepared phytosome gel by DPPH testing showed promising activity. The cytotoxic testing demonstrated bio-compatibility and an inhibitory effect on the growth of the MCF-7 cancer cell line of a loaded phospholipid aloe vera. The experimental observations demonstrated the potential of phytosome carriers to enhance the oral delivery of aloe vera by making way for its use in cancer therapy. (C) 2020 Elsevier Ltd. All rights reserved.