Metformin for prevention of hypertensive disorders of pregnancy in women with gestational diabetes or obesity: systematic review and meta-analysis of randomized trials

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KALAFAT E., ŞÜKÜR Y. E., Abdi A., Thilaganathan B., Khalil A.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, cilt.52, sa.6, ss.706-714, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 52 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/uog.19084
  • Dergi Adı: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.706-714
  • Anahtar Kelimeler: hypertension, metformin, pre-eclampsia, prevention, weight gain, POLYCYSTIC-OVARY-SYNDROME, PREECLAMPSIA, INSULIN, ASPIRIN, PLACEBO, MELLITUS, OUTCOMES, PRETERM, MANAGEMENT, GLYBURIDE
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Objective Metformin has been reported to reduce the risk of pre-eclampsia. It is also known to influence soluble fms-like tyrosine kinase-1 level, which correlates significantly with the gestational age at onset and severity of pre-eclampsia. The main aim of this systematic review and meta-analysis of randomized trials was to determine whether metformin use is associated with the incidence of hypertensive disorders of pregnancy (HDP).