Robust optimization in spline regression models for multi-model regulatory networks under polyhedral uncertainty

Ozmen A., Kropat E., Weber G.

OPTIMIZATION, cilt.66, sa.12, ss.2135-2155, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Konu: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/02331934.2016.1209672
  • Sayfa Sayıları: ss.2135-2155


In our study, we integrate the data uncertainty of real-world models into our regulatory systems and robustify them. We newly introduce and analyse robust time-discrete target-environment regulatory systems under polyhedral uncertainty through robust optimization. Robust optimization has reached a great importance as a modelling framework for immunizing against parametric uncertainties and the integration of uncertain data is of considerable importance for the model's reliability of a highly interconnected system. Then, we present a numerical example to demonstrate the efficiency of our new robust regression method for regulatory networks. The results indicate that our approach can successfully approximate the target-environment interaction, based on the expression values of all targets and environmental factors.