In vivo solid phase microextraction sampling of human saliva for non-invasive and on-site monitoring

Bessonneau V., Boyaci E., Maciazek-Jurczyk M., Pawliszyn J.

ANALYTICA CHIMICA ACTA, cilt.856, ss.35-45, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 856
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.aca.2014.11.029
  • Dergi Adı: ANALYTICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.35-45
  • Anahtar Kelimeler: Saliva, In vivo sampling, Solid-phase microextraction, Doping substances, Steroids, CHROMATOGRAPHY-MASS SPECTROMETRY, VOLATILE ORGANIC-COMPOUNDS, ALTERNATIVE SPECIMENS, HORMONE MEASUREMENT, METABOLOME, LC/MS/MS, CORTISOL, TOOL, LC
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

On-site sample preparation is an analytical approach based on direct sampling from the system under investigation. It has the advantage of combining sampling and sample preparation into a single step, thus generally is fast, minimizes the potential sources of error and eliminates the risks for analytes instability. For such analysis solid phase microextraction in thin film geometry (TF-SPME) can provide robust and convenient in vivo sampling, offering in the same time faster analysis and higher extraction recovery (i.e., better sensitivity) due to large surface to volume ratio.