In vivo solid phase microextraction sampling of human saliva for non-invasive and on-site monitoring


Bessonneau V., Boyaci E., Maciazek-Jurczyk M., Pawliszyn J.

ANALYTICA CHIMICA ACTA, vol.856, pp.35-45, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 856
  • Publication Date: 2015
  • Doi Number: 10.1016/j.aca.2014.11.029
  • Journal Name: ANALYTICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.35-45
  • Keywords: Saliva, In vivo sampling, Solid-phase microextraction, Doping substances, Steroids, CHROMATOGRAPHY-MASS SPECTROMETRY, VOLATILE ORGANIC-COMPOUNDS, ALTERNATIVE SPECIMENS, HORMONE MEASUREMENT, METABOLOME, LC/MS/MS, CORTISOL, TOOL, LC

Abstract

On-site sample preparation is an analytical approach based on direct sampling from the system under investigation. It has the advantage of combining sampling and sample preparation into a single step, thus generally is fast, minimizes the potential sources of error and eliminates the risks for analytes instability. For such analysis solid phase microextraction in thin film geometry (TF-SPME) can provide robust and convenient in vivo sampling, offering in the same time faster analysis and higher extraction recovery (i.e., better sensitivity) due to large surface to volume ratio.