Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

Davidson P. M., Ozcelik H., Hasirci V., Reiter G., Anselme K.

ADVANCED MATERIALS, vol.21, no.35, pp.3586-3591, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 35
  • Publication Date: 2009
  • Doi Number: 10.1002/adma.200900582
  • Journal Name: ADVANCED MATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3586-3591
  • Middle East Technical University Affiliated: Yes

Abstract

Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.