Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

Davidson P. M., Ozcelik H., Hasirci V., Reiter G., Anselme K.

ADVANCED MATERIALS, cilt.21, sa.35, ss.3586-3591, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 35
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/adma.200900582
  • Dergi Adı: ADVANCED MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3586-3591
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.