Akademik Veri Yönetim Sistemi
JOURNAL OF MOLECULAR STRUCTURE, cilt.1321, ss.139921-139932, 2024 (SCI-Expanded)
In this study, Ce3+/Tb3+ co-doped, Eu3+ doped GdB3O6 phosphor particles were synthesized by sol-gel method,
coated with hydroxyapatite (HAP) and loaded with doxorubicin. Different chelating agents and surfactants
(Cetyltrimethylammonium bromide (CTAB), citric acid, glycine, ethylenediaminetetraacetic acid (EDTA) and
tartaric acid) were used in the synthesis in order to see their effect on the structure. While single phase Gadolinium
triborate, GdB3O6 was obtained by using CTAB in precursor solution in the synthesis and Gadolinium
orthoborate, GdBO3 produced when EDTA was used in precursor solution. Other organic molecules added to
precursor solution produced mixtures of both phases. The highest photoluminescence intensity was obtained in
the Gd0.95Ce0.025Tb0.025B3O6 and Gd0.825Eu0.175B3O6. In order to increase the drug loading efficiency, The
Gd0.825Eu0.175B3O6 core was coated with Calcium hydroxyapatite, HAP. The core had an average size of 458.65
nm which increased to 616.85 nm after coating as seen with dynamic light scattering (DLS). Gd0.825Eu0.175B3O6@
HAP particles were loaded with 7.82 % ± 0.80 wt doxorubicin and the release was studied at 37 ◦C in pH
7.4 phosphate-buffered saline (PBS) and pH 5.5 acetate buffer solutions. The total number of moles of drug
released versus luminescence intensity was measured during the release studies and real-time imaging studies
were carried out. Finally, cytotoxicity experiments were performed on HCT-116 colon cancer cells.