Perlite is a volcanic rock that contains relatively high amounts of SiO2 and Al2O3. Due to its proper chemical composition and glassy structure, it can be used as a pozzolanic addition in blended cements. In this study, ground perlite was used as a cement replacement material in blended cements. Several mortar mixes were prepared to investigate the performance of those cements. The results showed that perlite incorporation caused early age strength losses when compared to the control mortars containing only portland cement; however, the difference between them decreased in time due to the pozzolanic reactions. The strengths of the blended cements were still within the limits of the EN standards. Moreover, it was observed that use of ground perlite increased the durability of portland cement mixes.