The present research examines chemistry course achievement in relation to the academic self-concept, attitudes towards the chemistry course and logical thinking skills. The study sample consisted of 252 students in a vocational high school in Ankara who voluntarily participated with convenience sampling method. In the research, the academic self-concept and logical thinking were found be significant predictors on academic achievement. As a result of discriminant analysis, the academic self-concept and logical thinking were determined to be the variables which distinguish successful from unsuccessful students. The classification of successful and unsuccessful students by distinctive variables was found to be successful at 69.4%.