Examining facial emotion recognition as an intermediate phenotype for psychosis: Findings from the EUGEI study


Fusar-Poli L., Pries L., van Os J., Erzin G., Delespaul P., Kenis G., ...More

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, vol.113, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 113
  • Publication Date: 2022
  • Doi Number: 10.1016/j.pnpbp.2021.110440
  • Journal Name: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, PASCAL, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Keywords: Schizophrenia, Emotion, Social cognition, Schizotypal traits, Polygenic risk score, SOCIAL COGNITION, STRUCTURED INTERVIEW, UNAFFECTED SIBLINGS, POLYGENIC RISK, GENETIC RISK, SCHIZOPHRENIA, INDIVIDUALS, ASSOCIATION, RELIABILITY, IMPUTATION

Abstract

Background: Social cognition impairments, such as facial emotion recognition (FER), have been acknowledged since the earliest description of schizophrenia. Here, we tested FER as an intermediate phenotype for psychosis using two approaches that are indicators of genetic risk for schizophrenia: the proxy-genetic risk approach (family design) and the polygenic risk score for schizophrenia (PRS-SCZ).