A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis

Caglayan Z., Demircan Yalcin Y., KÜLAH H.

MICROMACHINES, cilt.11, sa.11, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 11 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3390/mi11110990
  • Dergi Adı: MICROMACHINES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Communication Abstracts, Compendex, INSPEC, Metadex, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: biochip, biomems, biosensors, cancer cells, diagnostics, dielectrophoresis, lab-on-a-chip, marker-free particle manipulation, multidrug resistance, point-of-care, ON-A-CHIP, CIRCULATING TUMOR-CELLS, TOTAL ANALYSIS SYSTEMS, INSULATOR-BASED DIELECTROPHORESIS, DIELECTRIC-PROPERTIES, CANCER-CELLS, STEM-CELLS, SELECTIVE CONCENTRATION, CONTINUOUS SEPARATION, MULTIDRUG-RESISTANCE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

BioMEMS, the biological and biomedical applications of micro-electro-mechanical systems (MEMS), has attracted considerable attention in recent years and has found widespread applications in disease detection, advanced diagnosis, therapy, drug delivery, implantable devices, and tissue engineering. One of the most essential and leading goals of the BioMEMS and biosensor technologies is to develop point-of-care (POC) testing systems to perform rapid prognostic or diagnostic tests at a patient site with high accuracy. Manipulation of particles in the analyte of interest is a vital task for POC and biosensor platforms. Dielectrophoresis (DEP), the induced movement of particles in a non-uniform electrical field due to polarization effects, is an accurate, fast, low-cost, and marker-free manipulation technique. It has been indicated as a promising method to characterize, isolate, transport, and trap various particles. The aim of this review is to provide fundamental theory and principles of DEP technique, to explain its importance for the BioMEMS and biosensor fields with detailed references to readers, and to identify and exemplify the application areas in biosensors and POC devices. Finally, the challenges faced in DEP-based systems and the future prospects are discussed.