The effects of local and sustained release of fibroblast growth factor on wound heating in esophageal anastomoses


Fedakar-Senyucel M., Bingo-Kologlu M., Vargun R., Akbay C., Sarac F. N. , Renda N., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.43, no.2, pp.290-295, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jpedsurg.2007.10.016
  • Title of Journal : JOURNAL OF PEDIATRIC SURGERY
  • Page Numbers: pp.290-295
  • Keywords: esophagus, anastomosis, FGF, wound healing, ATRESIA, HYDROGEL, GELATIN, TISSUE

Abstract

Background/ Purpose: Postsurgical complications, such as anastomotic leaks in patients with esophageal atresia, have remained unchanged during the last 3 decades. Growth factors enhance healing in several wound-healing models. Therefore, an experimental study was used to evaluate the effects of local and sustained release of basic fibroblast growth factor (FGF) on wound healing in esophageal anastomoses.