The effects of local and sustained release of fibroblast growth factor on wound heating in esophageal anastomoses

Fedakar-Senyucel, Mine; Bingo-Kologlu, Meltem; Vargun, Rahsan; Akbay, Canan; Sarac, F.; Renda, Nurten; Hasirci, NESRİN; Gollu, Gulnur; DİNDAR, HÜSEYİN

doi:10.1016/j.jpedsurg.2007.10.016

The effects of local and sustained release of fibroblast growth factor on wound heating in esophageal anastomoses

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Fedakar-Senyucel M., Bingo-Kologlu M., Vargun R., Akbay C., Sarac F. N., Renda N., ...More

JOURNAL OF PEDIATRIC SURGERY, vol.43, no.2, pp.290-295, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 43 Issue: 2
Publication Date: 2008
Doi Number: 10.1016/j.jpedsurg.2007.10.016
Journal Name: JOURNAL OF PEDIATRIC SURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.290-295
Keywords: esophagus, anastomosis, FGF, wound healing, ATRESIA, HYDROGEL, GELATIN, TISSUE
Middle East Technical University Affiliated: Yes

Abstract

Background/ Purpose: Postsurgical complications, such as anastomotic leaks in patients with esophageal atresia, have remained unchanged during the last 3 decades. Growth factors enhance healing in several wound-healing models. Therefore, an experimental study was used to evaluate the effects of local and sustained release of basic fibroblast growth factor (FGF) on wound healing in esophageal anastomoses.