Design and construction of protein and peptide-based self-assembled nanostructures
Design, Principle and Application of Self-Assembled Nanobiomaterials in Biology and Medicine, Elsevier, ss.193-204, 2022
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/b978-0-323-90984-6.00011-8
- Yayınevi: Elsevier
- Sayfa Sayıları: ss.193-204
- Anahtar Kelimeler: bio-template, nanofabrication, nanoplatforms, Peptide, protein, self-assembly
- Orta Doğu Teknik Üniversitesi Adresli: Hayır
Özet
Self-assembly is the driving force for the formation of biological materials. From nucleic acid conformations to more complex cellular organizations, self-assembling structures shape biological functionality. So, the design of self-assembling biomolecular structures holds a great advantage for enhanced material properties. In biological processes, inorganic structures are created in a hierarchical fashion utilizing biomolecule-based templates. Since they have recognition and self-assembly properties, biomolecules can control highly organized inorganic material formation in nature. The bio-templating approach takes advantage of biomolecules’ self-assembly properties to develop new nanostructures with superior chemical and physical properties. Here, peptides and proteins including β-sheets, β-hairpins, α-helix, amyloid, capsid, ferritin, and albumin, used in the formation of nanostructures with desired functionality under mild environmental conditions, and their applications are discussed.