The objective of this study was to investigate physicians' perceptions to use mobile health applications in practice, and to identify influencing factors to use the technology. An mHealth technology acceptance model was proposed (M-TAM), and a cross-sectional survey was implemented using structured questionnaire to collect data. Online tools were used for inviting participants (physicians) and data collection from Turkey. The data was analyzed using Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM). A total of 128 physicians participated in the survey. The model explained the perception of physicians towards mHealth application use by 51% of total variance. The influential factors were identified as Effort Expectancy, Mobile Anxiety, Perceived Service Availability and Technical Training and Support. The study provided a new model to the literature of health information technology. Findings of the research contributed by unveiling latent constructs and their influence on physicians' perceptions towards a new healthcare technology: mHealth applications.