Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite


Uysal I., Severcan F., TEZCANER A., EVİS Z.

PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL, vol.24, no.4, pp.340-349, 2014 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.pnsc.2014.06.004
  • Journal Name: PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.340-349
  • Keywords: Hydroxyapatite, Co-doping, Microstructure, Microhardness, Biocompatibility, IN-VITRO, NANOCRYSTALLINE HYDROXYAPATITE, TRICALCIUM PHOSPHATE, OSTEOBLAST RESPONSE, BONE, ZN, COMPOSITES, ANTIBACTERIAL, MAGNESIUM, SPECTROSCOPY

Abstract

Hydroxyapatite (HA) co-doped with Zn2+ and F ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn2+ and F ions incorporation into HA structure. Co-doping of Zn2+ and F ions decreased unit cell volume of HA and decreased grain sizes. Zn2+ or 5 mol% F- addition into HA significantly Unproved its density. Microhardness was increased with Zn2+ addition and further increase was detected with F- co-doping. Zn2+ and F- co-doped samples had higher fracture toughness than pure HA. Zn2+ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F- addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications. (C) 2014 Chinese Materials Research Society. Production and hosting by Elsevier B.V. All rights reserved.