An economic, structurally effective and practically applicable strengthening technique was developed for reinforced concrete (RC) framed buildings. The idea of the technique is to convert the existing hollow brick infill wall into a load carrying system acting as a cast-in-place RC infill wall by bonding relatively thin high strength precast concrete PC panels to the plastered hollow brick infill. For this purpose, a total of eight one-third scale, one bay, one story frames were tested under reversed-cyclic lateral loads. Test frames were designed and constructed with common deficiencies observed in practice. Four different panel types were used for strengthening. Test results showed that both strength and stiffness of the frames were significantly improved by the introduction of PC panels. Experimental results were compared with the analytical approaches suggested by the authors.