Phospholipid Complexation of General Anesthetics in Fluid Bilayers

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Turkyilmaz S., Mitomo H., Chen W., Regen S. L.

LANGMUIR, cilt.26, sa.8, ss.5309-5311, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 8
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1021/la100712y
  • Dergi Adı: LANGMUIR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.5309-5311
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

A nearest-neighbor recogntion analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a funamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC Forms 1:1 complexes with CHCl3 in both membranes in the fluid bilayer state.