Crosslinking of Trimethylene Carbonate and D,L-Lactide (Co-) Polymers by Gamma Irradiation in the Presence of Pentaerythritol Triacrylate


Bat E., van Kooten T. G. , Feijen J., Grijpma D. W.

MACROMOLECULAR BIOSCIENCE, vol.11, no.7, pp.952-961, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.1002/mabi.201100031
  • Journal Name: MACROMOLECULAR BIOSCIENCE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.952-961
  • Keywords: crosslinking aids/agents, gamma irradiation, lactides, networks, trimethylene carbonate, IN-VITRO DEGRADATION, 1,3-TRIMETHYLENE CARBONATE, MECHANICAL-PROPERTIES, EPSILON-CAPROLACTONE, MOLECULAR-WEIGHT, POLY(TRIMETHYLENE CARBONATE), BIODEGRADABLE POLYMERS, POLY(L-LACTIC ACID), TISSUE-RESPONSE, VIVO BEHAVIOR

Abstract

High-molecular-weight (co) polymers of trimethylene carbonate and D, L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 +/- 5 to 96 +/- 1 are obtained from non-crystalline (co) polymers. Glass transition temperatures and elastic moduli of the networks can be varied by adjusting the copolymer composition. The PETA-containing (co) polymer networks are not cytotoxic. Upon incubation in macrophage cultures for 14 d, all (co) polymer films and PETA-containing network films erode to varying extents, showing that these materials can be degraded by cell-mediated erosion processes. This method is very useful for the facile preparation of TMC- and DLLA-containing form-stable networks from high-molecular-weight polymers.