Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer

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TASKOPARAN B., SEZA E. G., Demirkol S., TUNCER S., Stefek M., Gure A. O., ...Daha Fazla

CELLULAR ONCOLOGY, cilt.40, sa.6, ss.563-578, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s13402-017-0351-7
  • Dergi Adı: CELLULAR ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.563-578
  • Anahtar Kelimeler: AKR1B1, AKR1B10, Colorectal cancer, Inflammation, Motility, Prognosis, NF-KAPPA-B, BREAST-CANCER, CELL-PROLIFERATION, INHIBITION, EXPRESSION, GROWTH, IDENTIFICATION, INFLAMMATION, METASTASIS, TRANSITION
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Aldo-keto reductases (including AKR1B1 and AKR1B10) constitute a family of oxidoreductases that have been implicated in the pathophysiology of diabetes and cancer, including colorectal cancer (CRC). Available data indicate that, despite their similarities in structure and enzymatic functions, their roles in CRC may be divergent. Here, we aimed to determine the expression and functional implications of AKR1B1 and AKR1B10 in CRC.