Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model Laboratory investigation

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Cemil B., Tun K., Kaptanoglu E., Kaymaz F., Cevirgen B., CÖMERT A., ...More

JOURNAL OF NEUROSURGERY-SPINE, vol.11, no.6, pp.758-763, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.3171/2009.6.spine08580
  • Journal Name: JOURNAL OF NEUROSURGERY-SPINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.758-763
  • Keywords: epidural fibrosis, failed back syndrome, laminectomy, mitomycin C, pimecrolimus, TOPICAL CALCINEURIN INHIBITORS, LAMINECTOMY SCAR FORMATION, SDZ ASM 981, MITOMYCIN-C, ATOPIC-DERMATITIS, ANTIINFLAMMATORY DRUG, PERIDURAL FIBROSIS, CREAM 1-PERCENT, SKIN DISEASES, SURGERY
  • Middle East Technical University Affiliated: Yes

Abstract

Object. Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy. Extensive epidural fibrosis may be an important underlying cause of failed back syndrome. Pimecrolimus, an ascomycin derivative, is one of the new classes of immunomodulating macrolactams and was specifically developed for the treatment of inflammatory diseases. This study examined the preventive effects of the local application of pimecrolimus in minimizing spinal epidural fibrosis in a rat laminectomy model.