Yalçin Şahiner Ş., Baysal D., Vayisoğlu T., Uçar Hasanli Z., Neşelioğlu S., Avcioğlu G., ...Daha Fazla
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, cilt.20, ss.1-13, 2026 (SCI-Expanded, Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
20
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Basım Tarihi:
2026
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Doi Numarası:
10.3389/fnbeh.2026.1933257
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Dergi Adı:
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
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Derginin Tarandığı İndeksler:
Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Scopus, Science Citation Index Expanded (SCI-EXPANDED), EMBASE, Psycinfo, Directory of Open Access Journals, Zoological Record
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Sayfa Sayıları:
ss.1-13
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Orta Doğu Teknik Üniversitesi Adresli:
Evet
Özet
Introduction
Chronic heroin use disturbs body’s redox (oxidant-antioxidant) balance, together with dynamic thiol-disulfide balance and ischemia-modified albumin; which are two distinct blood markers that may reflect the oxidative and ischemic load in substance dependence. It is still unclear whether these markers change across the clinical phases of heroin use disorder (HUD), or whether they relate to the affective and behavioral symptoms that dominate the clinical picture.
Methods
In this cross-sectional study, 101 adults meeting DSM-5 criteria for HUD were split into a remission group (
n
= 52) and a detoxification group (
n
= 49). We measured serum native and total thiol, disulfide, the disulfide/native thiol, disulfide/total thiol and native thiol/total thiol ratios, and IMA. Participants also completed a symptom inventory, a craving measure, and scales for healthy-lifestyle behavior and nutrition attitude. Groups were compared with Student’s
t
-test or the Mann–Whitney
U
test, categorical variables with chi-square or Fisher’s exact test; associations were tested with Spearman correlations, and predictors of total thiol and IMA with multiple linear regression.
Results
Patients in detoxification group scored markedly higher on depression, anxiety, anger, somatic symptoms, suicidal ideation, psychosis, sleep disturbance, dissociation and craving (all
p
≤ 0.001), and lower on healthy-lifestyle and nutrition-attitude scores (
p
< 0.001). In contrast, no thiol/disulfide measure or IMA differed between phases. IMA correlated positively with depression (
r
= 0.254) and craving (
r
= 0.209); whereas the disulfide/thiol ratios correlated negatively, and native thiol/total thiol positively with healthy-lifestyle and nutrition-attitude scores. Regression models for total thiol and IMA were not statistically significant.
Conclusion
In HUD, redox and ischemia markers appear to follow symptom severity; especially depression, craving and health behavior, rather than the treatment phase itself. IMA, in particular, may reflect an oxidative and inflammatory component of mood regulation and craving.