Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug

PARSIAN M., UNSOY G., MUTLU P., Yalcin S., TEZCANER A., GÜNDÜZ U.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.784, ss.121-128, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 784
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejphar.2016.05.016
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.121-128
  • Anahtar Kelimeler: Chitosan, Magnetic nanoparticles, Gemcitabine, Targeted drug delivery, Breast cancer, DELIVERY, BIOCOMPATIBILITY, BIODISTRIBUTION, ENDOCYTOSIS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, biodegradability, low toxicity and targetability under magnetic field. This study aimed to increase the cellular uptake and efficacy of Gemcitabine.