Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug


PARSIAN M., UNSOY G., MUTLU P. , Yalcin S., TEZCANER A. , GÜNDÜZ U.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.784, ss.121-128, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 784
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.ejphar.2016.05.016
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.121-128

Özet

Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, biodegradability, low toxicity and targetability under magnetic field. This study aimed to increase the cellular uptake and efficacy of Gemcitabine.