Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug

PARSIAN M., UNSOY G., MUTLU P., Yalcin S., TEZCANER A., GÜNDÜZ U.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.784, pp.121-128, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 784
  • Publication Date: 2016
  • Doi Number: 10.1016/j.ejphar.2016.05.016
  • Journal Name: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.121-128
  • Keywords: Chitosan, Magnetic nanoparticles, Gemcitabine, Targeted drug delivery, Breast cancer, DELIVERY, BIOCOMPATIBILITY, BIODISTRIBUTION, ENDOCYTOSIS
  • Middle East Technical University Affiliated: Yes

Abstract

Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, biodegradability, low toxicity and targetability under magnetic field. This study aimed to increase the cellular uptake and efficacy of Gemcitabine.