Catalytic enantioselective addition of diethylzinc to aldehydes using aziridine based chiral ligands

BULUT A., ASLAN A., İZGÜ E. C., Dogan O.

TETRAHEDRON-ASYMMETRY, vol.18, no.8, pp.1013-1016, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1016/j.tetasy.2007.04.013
  • Journal Name: TETRAHEDRON-ASYMMETRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1013-1016
  • Middle East Technical University Affiliated: Yes

Abstract

The readily available ferrocenyl substituted aziridinylmethanol 1 (FAM-1) was used as a chiral catalyst in the diethylzinc addition reaction to aromatic and aliphatic aldehydes to give secondary alcohols in high yields and up to 99% enantiomeric excess at room temperature. The catalyst can be recovered and used without losing its activity. (c) 2007 Elsevier Ltd. All rights reserved.