Structural and functional damages of whole body ionizing radiation on rat brain homogenate membranes and protective effect of amifostine

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ÇAKMAK G., Severcan M., Zorlu F., Severcan F.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol.92, no.12, pp.837-848, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 92 Issue: 12
• Publication Date: 2016
• Doi Number: 10.1080/09553002.2016.1230237
• Journal Name: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.837-848
• Keywords: Amifostine, brain homogenate membrane, FTIR spectroscopy, ionizing radiation, lipid peroxidation, protein secondary structure, TRANSFORM INFRARED-SPECTROSCOPY, LIPID-PEROXIDATION, OXIDATIVE STRESS, SECONDARY STRUCTURE, ENDOTHELIAL-CELLS, WR-2721, IRRADIATION, INHIBITION, PROTEINS, DYNAMICS
• Middle East Technical University Affiliated: Yes

Abstract

Purpose: To investigate the effects of whole body ionizing radiation at a sublethal dose on rat brain homogenate membranes and the protective effects of amifostine on these systems at molecular level.