Structural and functional damages of whole body ionizing radiation on rat brain homogenate membranes and protective effect of amifostine


ÇAKMAK G., Severcan M., Zorlu F., Severcan F.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol.92, no.12, pp.837-848, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.1080/09553002.2016.1230237
  • Title of Journal : INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
  • Page Numbers: pp.837-848
  • Keywords: Amifostine, brain homogenate membrane, FTIR spectroscopy, ionizing radiation, lipid peroxidation, protein secondary structure, TRANSFORM INFRARED-SPECTROSCOPY, LIPID-PEROXIDATION, OXIDATIVE STRESS, SECONDARY STRUCTURE, ENDOTHELIAL-CELLS, WR-2721, IRRADIATION, INHIBITION, PROTEINS, DYNAMICS

Abstract

Purpose: To investigate the effects of whole body ionizing radiation at a sublethal dose on rat brain homogenate membranes and the protective effects of amifostine on these systems at molecular level.